Negative regulation of monocyte differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of monocyte differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF40, WWP1, and UPF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF40 grouped by Negative regulation of monocyte differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RNF40 →	+0.334	+0.206	.003	.005	3	5
SOFT_TISSUE	WWP1 →	+0.336	+0.350	.001	<.001	3	4
LUNG_SCLC	UPF1 →	+0.223	+1.357	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	ADPRS →	+0.177	+0.208	.009	.003	3	4
BONE	LTBP1 →	-0.430	-0.447	.001	.005	3	4
SKIN	SFTPB →	-0.187	-0.147	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF40 by Negative regulation of monocyte differentiation activity — OVARY

Explore this box plot interactively →