Negative regulation of megakaryocyte differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of megakaryocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCL_T121, RECQL4_S251, and RRM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of megakaryocyte differentiation activity versus NCL_T121 in HNSC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NCL_T121 →	+0.489	+0.106	.001	<.001	3	5
LUAD	RECQL4_S251 →	+0.693	+0.061	.005	.005	3	4
LUAD	RRM2 →	+0.579	+0.053	<.001	<.001	3	4
LUAD	TACC2_S2226 →	-0.535	-0.050	.003	<.001	3	4
GBM	CHAF1B_S410 →	+0.755	+0.063	.007	.004	3	4
LUAD	CLSPN_S83 →	+0.918	+0.059	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045653 vs NCL_T121 — HNSC

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