Negative regulation of megakaryocyte differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of megakaryocyte differentiation pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 19 member genes.

The strongest signal is observed in small cell lung cancer (SCLC), where higher Negative regulation of megakaryocyte differentiation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and BLCA, show the opposite pattern, with higher activity associated with better survival.

SCLC, MESO, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	All	0.386	0.717	<.001	104	view →
MESO	OS	Median	All	0.671	0.435	<.001	95	view →
KIRP	DFS	Tertile	All	0.874	0.991	<.001	88	view →
UCS	DFS	Median	II,III,IV	0.156	0.570	.002	60	view →
BLCA	DFS	Median	All	0.570	0.443	.002	48	view →
ACC	DFS	Quartile	All	0.431	0.813	.001	41	view →
COAD	DFS	Median	All	0.791	0.609	.006	30	view →
LAML	DFS	Median	All	0.250	0.523	.016	24	view →
DLBC	OS	Tertile	III,IV	0.272	1.000	.038	18	view →
UVM	OS	Median	All	0.419	0.833	.009	15	view →
OV	DFS	Tertile	IV	0.543	0.286	.021	12	view →
CHOL	OS	Quartile	All	0.308	0.645	.038	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0045653–SCLC (DFS)

Open the SCLC breakdown →