Negative regulation of megakaryocyte differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of megakaryocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HBA2, HBA1, and HBB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of megakaryocyte differentiation activity versus HBA2 in OV (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HBA2 →	+1.538	+0.146	<.001	<.001	3	5
BRCA	HBA1 →	+1.406	+0.242	.001	.004	2	6
PDAC	HBB →	+1.726	+0.175	.005	.001	3	5
OV	DUSP1 →	+1.125	+0.148	.005	.005	2	6
GBM	RGS2 →	+0.920	+0.160	<.001	<.001	3	4
LUAD	ALAS2 →	+0.568	+0.177	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045653 vs HBA2 — OV

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