Negative regulation of megakaryocyte differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of megakaryocyte differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLVS2, SST, and PTPA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLVS2 grouped by Negative regulation of megakaryocyte differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CLVS2 →	-0.446	-0.291	.002	.001	3	6
BONE	SST →	+0.515	+0.240	.002	.004	3	5
LARGE_INTESTINE	PTPA →	-0.182	-0.154	.006	.004	3	5
BREAST	CDC42EP1 →	-0.189	-0.162	.002	<.001	3	5
BREAST	BZW2 →	-0.147	-0.102	.005	.002	3	5
CNS	RAG2 →	+0.194	+0.120	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLVS2 by Negative regulation of megakaryocyte differentiation activity — BONE

Explore this box plot interactively →