Negative regulation of megakaryocyte differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of megakaryocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TJP3, CDCA8, and BUD13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of megakaryocyte differentiation activity versus TJP3 in STOMACH (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TJP3 →	-2.960	-0.091	<.001	.001	3	5
BLOOD_Leukemia	CDCA8 →	+0.634	+0.043	.005	.004	3	4
CNS	BUD13 →	+0.911	+0.106	.005	.002	3	4
BREAST	DDX10 →	+0.710	+0.073	.004	.003	3	4
LUNG_NSCLC_LUAD	S100A14 →	-4.669	-0.120	.003	.001	3	4
BREAST	FUT11 →	+1.035	+0.084	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045653 vs TJP3 — STOMACH

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