Regulation of megakaryocyte differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of megakaryocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C4orf46, LSM6, and HMGB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of megakaryocyte differentiation activity versus C4orf46 in BREAST (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	C4orf46 →	+0.671	+0.129	.006	.003	3	7
CNS	LSM6 →	+0.787	+0.127	<.001	.007	3	6
LARGE_INTESTINE	HMGB2 →	+1.020	+0.216	<.001	<.001	3	6
LUNG_NSCLC_LUSC	TSPYL4 →	+0.862	+0.202	.004	.002	3	6
LARGE_INTESTINE	HNRNPA1 →	+0.591	+0.181	<.001	.001	3	6
KIDNEY	TBC1D15 →	+0.704	+0.180	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045652 vs C4orf46 — BREAST

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