Positive regulation of macrophage differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of macrophage differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NXN, CIAO3, and ZNF701, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of macrophage differentiation activity versus NXN in LUNG_SCLC (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NXN →	-3.313	-1.911	.001	<.001	3	4
BLOOD_Lymphoma	CIAO3 →	+1.073	+1.182	<.001	.002	3	4
BLOOD_Lymphoma	ZNF701 →	+1.673	+1.004	<.001	<.001	3	4
BLOOD_Lymphoma	RNASEH2C →	+0.728	+1.167	.001	<.001	3	4
STOMACH	TMED9 →	+0.811	+0.630	.006	.004	3	4
CNS	ACTR3 →	+0.549	+0.710	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045651 vs NXN — LUNG_SCLC

Explore this scatter interactively →