Regulation of macrophage differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of macrophage differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAFAH2, COX18, and ZNF552, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macrophage differentiation activity versus PAFAH2 in STOMACH (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PAFAH2 →	-1.215	-0.742	.004	.009	3	5
STOMACH	COX18 →	-0.730	-1.126	<.001	.001	3	5
STOMACH	ZNF552 →	-1.098	-1.375	.001	.005	3	5
SOFT_TISSUE	MON2 →	-0.838	-1.142	<.001	.009	3	4
LUNG_SCLC	MARK4 →	-0.964	-1.017	.008	.003	3	4
STOMACH	PMM2 →	-1.126	-1.087	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045649 vs PAFAH2 — STOMACH

Explore this scatter interactively →