Negative regulation of T-helper 2 cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of T-helper 2 cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMHD1_S33, ITGAL_S1140, and SAMHD1_T592, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T-helper 2 cell differentiation activity versus SAMHD1_S33 in LSCC (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAMHD1_S33 →	-0.631	-0.087	<.001	<.001	3	7
CCRCC	ITGAL_S1140 →	-0.951	-0.081	<.001	<.001	3	7
LUAD	SAMHD1_T592 →	-0.685	-0.059	<.001	<.001	3	6
HNSC	DOCK10 →	-0.288	-0.065	.002	.002	3	6
LSCC	STAT1 →	-0.684	-0.099	<.001	<.001	3	6
LSCC	CYBA_T147 →	-0.808	-0.082	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045629 vs SAMHD1_S33 — LSCC

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