Regulation of T-helper 2 cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of T-helper 2 cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RENBP, AIF1, and MYO1F, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 2 cell differentiation activity versus RENBP in GBM (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RENBP →	+0.531	+0.075	<.001	<.001	3	8
GBM	AIF1 →	+0.755	+0.100	<.001	<.001	3	8
GBM	MYO1F →	+0.557	+0.093	<.001	<.001	3	8
COAD	PLEKHO2 →	+0.353	+0.041	.001	<.001	3	8
GBM	WAS →	+0.526	+0.098	<.001	<.001	3	8
GBM	MNDA →	+1.048	+0.122	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045628 vs RENBP — GBM

Explore this scatter interactively →