Regulation of T-helper 2 cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of T-helper 2 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIWIL4, BCL6, and SYT11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T-helper 2 cell differentiation activity versus PIWIL4 in HNSC (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PIWIL4 →	-0.508	-0.356	.003	.006	3	4
GBM	BCL6 →	+0.851	+0.618	<.001	<.001	3	4
GBM	SYT11 →	-0.332	-0.446	.001	<.001	3	4
GBM	TCF4 →	-0.510	-0.480	.001	.003	3	4
CCRCC	KCNMB1 →	-0.349	-0.566	.002	<.001	3	3
GBM	NGRN →	-0.433	-0.643	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045628 vs PIWIL4 — HNSC

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