Regulation of T-helper 2 cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of T-helper 2 cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRK, ZNF155, and EIF4B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRK grouped by Regulation of T-helper 2 cell differentiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CRK →	+0.183	+0.114	.004	.003	3	6
LUNG_NSCLC_LUSC	ZNF155 →	-0.308	-0.216	.002	.001	3	4
LUNG_NSCLC_LUSC	EIF4B →	-0.368	-0.132	<.001	.005	3	4
SKIN	API5 →	+0.181	+0.200	.002	<.001	3	4
LIVER	PKD1 →	-0.326	-0.229	.003	<.001	3	4
KIDNEY	FCGR1B →	-0.223	-0.138	<.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRK by Regulation of T-helper 2 cell differentiation activity — BLOOD_Leukemia

Explore this box plot interactively →