Regulation of T-helper 2 cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of T-helper 2 cell differentiation pathway is significantly associated with the drug response of multiple features, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are VSP34_8731, ascorbate (vitamin C), and VNLG/124, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VSP34_8731 grouped by Regulation of T-helper 2 cell differentiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VSP34_8731 →	-0.859	-0.289	.038	<.001	3	1
LARGE_INTESTINE	ascorbate (vitamin C) →	-0.833	-0.407	.039	.011	3	1
LARGE_INTESTINE	VNLG/124 →	-0.239	-0.326	.013	.004	3	1
LARGE_INTESTINE	glutathione →	-0.366	-0.375	.028	.026	2	1
LARGE_INTESTINE	CAP-232 →	-0.985	-0.290	.017	.029	2	1
BLOOD_Lymphoma	AS605240 →	+0.764	+0.225	.010	.022	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VSP34_8731 by Regulation of T-helper 2 cell differentiation activity — LARGE_INTESTINE

Explore this box plot interactively →