Positive regulation of T-helper cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of T-helper cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, CTSB, and LRP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T-helper cell differentiation activity versus ANXA1 in BREAST (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ANXA1 →	+4.582	+0.517	<.001	<.001	3	9
BLOOD_Lymphoma	CTSB →	+2.591	+0.775	.004	.005	3	5
KIDNEY	LRP1 →	+1.920	+0.217	<.001	<.001	2	5
BREAST	PRNP →	+2.567	+0.357	<.001	.004	3	4
BLOOD_Lymphoma	BRI3BP →	-1.271	-0.889	.003	<.001	3	4
BREAST	FXYD5 →	+2.740	+0.301	<.001	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045624 vs ANXA1 — BREAST

Explore this scatter interactively →