Negative regulation of T-helper cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of T-helper cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL6, SLFN5, and PDXP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of T-helper cell differentiation activity versus BCL6 in CCRCC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BCL6 →	+0.639	+0.271	<.001	.001	3	4
GBM	SLFN5 →	+0.696	+0.297	<.001	<.001	3	4
GBM	PDXP →	-0.600	-0.426	<.001	<.001	3	4
GBM	DENND5B-AS1 →	-0.374	-0.329	.004	<.001	3	4
HNSC	SOCS2 →	-0.527	-0.196	.008	.001	3	3
HNSC	DANCR →	+0.377	+0.147	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045623 vs BCL6 — CCRCC

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