Positive regulation of lymphocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of lymphocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM7, NEK3, and PKDCC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lymphocyte differentiation activity versus MCM7 in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MCM7 →	+0.755	+0.218	<.001	.001	3	6
BLOOD_Leukemia	NEK3 →	-1.801	-0.166	<.001	.001	3	5
LARGE_INTESTINE	PKDCC →	-2.608	-0.187	.001	.002	3	5
PANCREAS	ARID1A →	+0.761	+0.315	.007	<.001	2	6
BLOOD_Lymphoma	RAP2B →	+0.993	+0.208	<.001	.001	3	5
PANCREAS	RLN2 →	+1.254	+0.326	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045621 vs MCM7 — LUNG_NSCLC_LUAD

Explore this scatter interactively →