Regulation of lymphocyte differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of lymphocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR222HG, TMEM199, and HMGA1P2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphocyte differentiation activity versus MIR222HG in BRCA (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR222HG →	+1.310	+0.246	.007	<.001	3	2
COAD	TMEM199 →	+0.299	+0.503	<.001	.001	3	2
COAD	HMGA1P2 →	+0.652	+0.640	.005	<.001	3	2
BRCA	SLC1A5 →	-0.749	-0.223	.005	.002	3	1
BRCA	APLP1 →	-4.249	-0.223	.007	.002	3	1
BRCA	RASIP1 →	+1.276	+0.223	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045619 vs MIR222HG — BRCA

Explore this scatter interactively →