Regulation of lymphocyte differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of lymphocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RGS19_S72, RIN2_T332, and RIOX1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphocyte differentiation activity versus RGS19_S72 in COAD (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RGS19_S72 →	+0.497	+0.667	<.001	.003	3	1
COAD	RIN2_T332 →	-0.812	-1.211	<.001	<.001	3	1
COAD	RIOX1 →	+0.221	+0.475	<.001	<.001	3	1
COAD	ASB9 →	+0.694	+0.896	<.001	<.001	3	1
COAD	SAMSN1_S347 →	+0.495	+0.622	<.001	.001	3	1
COAD	SASH1_S1051 →	-0.412	-0.937	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045619 vs RGS19_S72 — COAD

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