Regulation of lymphocyte differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of lymphocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF4A, ENOX2, and TPX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF4A grouped by Regulation of lymphocyte differentiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KIF4A →	-0.726	-0.124	.006	.006	3	5
BLOOD_Leukemia	ENOX2 →	-0.611	-0.124	.005	.006	3	4
BLOOD_Leukemia	TPX2 →	-0.866	-0.142	.009	.002	3	4
PANCREAS	ALYREF →	-0.724	-0.193	<.001	.005	3	4
PANCREAS	IPO5 →	-1.337	-0.278	<.001	.001	3	4
LUNG_SCLC	RCN3 →	-2.083	-0.257	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF4A by Regulation of lymphocyte differentiation activity — BLOOD_Leukemia

Explore this box plot interactively →