Regulation of keratinocyte differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of keratinocyte differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KRT23, PPL, and TLE1_T312, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of keratinocyte differentiation activity versus KRT23 in PDAC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	KRT23 →	+1.200	+0.042	<.001	<.001	3	5
UCEC	PPL →	+0.839	+0.082	<.001	<.001	3	5
GBM	TLE1_T312 →	+0.679	+0.052	.001	.001	3	4
UCEC	EVPL_S2025 →	+0.924	+0.075	<.001	<.001	3	4
LUAD	GRHL1_T208 →	+0.768	+0.067	<.001	<.001	3	4
CCRCC	PRRC2B_S556 →	+0.314	+0.028	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045616 vs KRT23 — PDAC

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