Regulation of keratinocyte differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of keratinocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are E2F1, DLGAP5, and UBE2C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of keratinocyte differentiation activity versus E2F1 in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	E2F1 →	+1.023	+0.741	<.001	.003	3	6
LSCC	DLGAP5 →	+0.840	+0.372	<.001	.001	3	6
BRCA	UBE2C →	+0.871	+0.559	<.001	<.001	3	6
LSCC	VRK1 →	+0.844	+0.519	<.001	<.001	3	5
GBM	FAM83D →	+0.741	+0.633	.002	.003	2	6
BRCA	FANCE →	+0.688	+0.736	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045616 vs E2F1 — BRCA

Explore this scatter interactively →