Regulation of endothelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of endothelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZC3HC1_S24, SEPTIN2, and SEPTIN7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endothelial cell differentiation activity versus ZC3HC1_S24 in LUAD (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZC3HC1_S24 →	-0.733	-0.149	<.001	.001	3	7
PDAC	SEPTIN2 →	+0.250	+0.192	<.001	<.001	3	6
PDAC	SEPTIN7 →	+0.239	+0.209	<.001	<.001	3	6
UCEC	SORBS3 →	+0.438	+0.146	<.001	<.001	3	6
UCEC	CNRIP1 →	+0.802	+0.246	<.001	<.001	3	6
BRCA	DAPK3 →	+0.407	+0.172	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045601 vs ZC3HC1_S24 — LUAD

Explore this scatter interactively →