Regulation of endothelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of endothelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCFC2, TENT4B, and MAK16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GCFC2 grouped by Regulation of endothelial cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GCFC2 →	+0.635	+1.156	.002	<.001	3	4
PANCREAS	TENT4B →	+0.666	+0.712	<.001	.008	3	4
LARGE_INTESTINE	MAK16 →	+0.854	+0.926	.005	.007	3	4
LARGE_INTESTINE	DTWD2 →	+0.737	+1.121	.001	<.001	3	4
LARGE_INTESTINE	GRIN3A →	+0.089	+0.722	.002	.007	3	4
LARGE_INTESTINE	DCP1A →	+0.614	+1.214	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GCFC2 by Regulation of endothelial cell differentiation activity — BREAST

Explore this box plot interactively →