Regulation of endothelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of endothelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPSM1, MPZL2, and RUSC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endothelial cell differentiation activity versus GPSM1 in STOMACH (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GPSM1 →	-2.074	-0.427	.003	<.001	2	7
STOMACH	MPZL2 →	+3.880	+0.421	<.001	.001	3	5
STOMACH	RUSC2 →	-1.334	-0.382	.005	<.001	3	5
LUNG_NSCLC_LUAD	CEP164 →	-0.758	-0.311	<.001	<.001	3	5
LUNG_NSCLC_LUAD	F11R →	+2.212	+0.420	<.001	<.001	3	5
LUNG_NSCLC_LUAD	MPZL3 →	+1.650	+0.341	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045601 vs GPSM1 — STOMACH

Explore this scatter interactively →