Positive regulation of fat cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDLRAP1, KBTBD11, and LINC01307, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fat cell differentiation activity versus LDLRAP1 in GBM (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LDLRAP1 →	+0.588	+0.415	<.001	.002	3	4
CCRCC	KBTBD11 →	-0.609	-0.537	.007	.005	3	3
PDAC	LINC01307 →	-0.023	-0.402	.006	<.001	3	3
LUAD	NEIL3 →	-0.654	-0.099	.001	.009	3	3
GBM	POC1A →	-0.594	-0.309	<.001	.006	3	3
LUAD	NDC80 →	-0.611	-0.099	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045600 vs LDLRAP1 — GBM

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