Regulation of fat cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS29, KIAA0040, and SLC19A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VPS29 grouped by Regulation of fat cell differentiation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	VPS29 →	-0.958	-0.267	.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	KIAA0040 →	-1.486	-0.185	<.001	<.001	3	4
LIVER	SLC19A2 →	-1.184	-0.272	<.001	<.001	3	4
BREAST	PLEKHM2 →	+0.937	+0.185	<.001	<.001	3	4
PANCREAS	IQCD →	-0.934	-0.168	.001	<.001	3	4
KIDNEY	PRDX6 →	+0.851	+0.361	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VPS29 by Regulation of fat cell differentiation activity — BLOOD_Myeloma

Explore this box plot interactively →