Positive regulation of regulatory T cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of regulatory T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HLA-B, HLA-C, and IFIT2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of regulatory T cell differentiation activity versus HLA-B in OESOPHAGUS (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HLA-B →	+3.724	+1.506	<.001	<.001	3	7
OESOPHAGUS	HLA-C →	+2.186	+1.506	<.001	<.001	3	6
BREAST	IFIT2 →	+2.003	+0.991	.003	.007	3	5
LIVER	MEST →	-2.084	-1.635	<.001	<.001	3	4
BLOOD_Lymphoma	EFR3A →	+1.412	+1.198	.001	.004	3	4
BLOOD_Lymphoma	TM7SF2 →	-1.263	-1.240	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045591 vs HLA-B — OESOPHAGUS

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