Regulation of gamma-delta T cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of gamma-delta T cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OTX2, RAC1, and CXCL9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OTX2 grouped by Regulation of gamma-delta T cell differentiation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OTX2 →	+0.137	+0.134	.005	.003	3	5
OVARY	RAC1 →	+0.281	+0.843	.009	.007	3	4
BLOOD_Leukemia	CXCL9 →	+0.232	+0.243	.003	.006	3	4
BLOOD_Leukemia	INCENP →	+0.456	+0.333	<.001	<.001	3	4
BLOOD_Myeloma	SORD2P →	+0.290	+0.205	<.001	.004	3	3
BLOOD_Myeloma	ARNTL2 →	+0.290	+0.322	.003	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OTX2 by Regulation of gamma-delta T cell differentiation activity — SKIN

Explore this box plot interactively →