Regulation of B cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GZMK, FGD2, and PARP15, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of B cell differentiation activity versus GZMK in UCEC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GZMK →	+0.626	+0.188	<.001	<.001	3	7
UCEC	FGD2 →	+0.669	+0.231	<.001	<.001	3	6
UCEC	PARP15 →	+0.707	+0.215	.001	<.001	3	6
HNSC	E2F3P1 →	+0.621	+0.280	.007	.009	3	6
UCEC	CCR5 →	+0.681	+0.216	<.001	<.001	3	6
UCEC	IKZF1 →	+0.660	+0.219	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045577 vs GZMK — UCEC

Explore this scatter interactively →