Regulation of B cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of B cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP14, SSRP1, and RIPK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of B cell differentiation activity versus MMP14 in OESOPHAGUS (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MMP14 →	+3.782	+0.896	<.001	.004	3	5
SKIN	SSRP1 →	-0.831	-0.290	.004	.006	3	4
BLOOD_Lymphoma	RIPK3 →	+1.179	+0.681	.002	.004	3	3
BLOOD_Lymphoma	SLC37A1 →	+1.554	+0.952	.007	.001	3	3
BLOOD_Lymphoma	PDE4DIP →	-2.142	-0.695	.002	.004	3	3
LARGE_INTESTINE	RPL23A →	-0.388	-1.005	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045577 vs MMP14 — OESOPHAGUS

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