Mast cell activation

Across TCGA cell cohorts, RNA activity of the Mast cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNAP23, FOXP4, and CRCP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mast cell activation activity versus SNAP23 in BREAST (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SNAP23 →	+0.836	+1.111	<.001	<.001	3	5
PANCREAS	FOXP4 →	+1.167	+1.206	.008	.001	3	4
LUNG_NSCLC_LUAD	CRCP →	+0.590	+0.992	<.001	<.001	3	4
BLOOD_Lymphoma	HLA-B →	-2.689	-0.998	.006	.002	3	4
BREAST	PLEKHJ1 →	+0.583	+0.909	.001	<.001	3	4
LIVER	FOXP1 →	+1.372	+1.496	.007	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045576 vs SNAP23 — BREAST

Explore this scatter interactively →