Positive regulation of cholesterol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of cholesterol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCC1, RAP2B, and ANO7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RCC1 grouped by Positive regulation of cholesterol biosynthetic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RCC1 →	+0.558	+0.908	.009	.009	3	4
OESOPHAGUS	RAP2B →	-0.700	-0.286	.009	.008	3	4
UPPER_AERODIGESTIVE_TRACT	ANO7 →	+0.681	+0.388	.002	.004	3	4
LUNG_SCLC	DUSP1 →	-1.618	-0.428	.004	<.001	3	3
STOMACH	OIP5 →	+0.642	+0.203	.002	<.001	3	3
STOMACH	MRPL2 →	+0.503	+0.173	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RCC1 by Positive regulation of cholesterol biosynthetic process activity — OVARY

Explore this box plot interactively →