Regulation of cholesterol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Regulation of cholesterol biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HEXA, HAAO, and EIF3H_S183, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cholesterol biosynthetic process activity versus HEXA in UCEC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HEXA →	+0.257	+0.044	.004	<.001	3	5
HNSC	HAAO →	+0.471	+0.073	.003	<.001	3	5
BRCA	EIF3H_S183 →	-0.538	-0.056	<.001	<.001	3	5
GBM	EZH2 →	-0.669	-0.039	.002	.001	3	5
BRCA	KIF2C →	-0.654	-0.051	<.001	<.001	3	5
GBM	MCM4 →	-0.705	-0.064	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045540 vs HEXA — UCEC

Explore this scatter interactively →