Photoreceptor cell maintenance

Across TCGA patient cohorts, RNA activity of the Photoreceptor cell maintenance pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EBI3, CHRDL1, and SMG7-AS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Photoreceptor cell maintenance activity versus EBI3 in LUAD (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EBI3 →	-0.326	-0.183	.004	.003	3	6
CCRCC	CHRDL1 →	-1.612	-1.010	.001	<.001	3	5
LUAD	SMG7-AS1 →	+0.495	+0.310	<.001	<.001	3	4
UCEC	SKAP1-AS1 →	-0.666	-0.247	.003	.004	3	4
UCEC	KIF9 →	+0.606	+0.265	<.001	.002	3	4
CCRCC	CMTM3 →	-0.416	-0.716	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045494 vs EBI3 — LUAD

Explore this scatter interactively →