Response to ether

Across TCGA patient cohorts, RNA activity of the Response to ether pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF438, GGT5, and PLAT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ether activity versus ZNF438 in LUAD (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZNF438 →	-0.260	-0.189	.001	<.001	3	4
GBM	GGT5 →	-0.562	-0.155	<.001	.002	3	4
UCEC	PLAT →	-0.589	-0.115	.002	.002	2	5
UCEC	HPCAL1 →	-0.425	-0.115	<.001	.002	3	4
CCRCC	SPTLC2 →	-0.408	-0.174	<.001	<.001	3	3
CCRCC	OR10AA1P →	-0.059	-0.091	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045472 vs ZNF438 — LUAD

Explore this scatter interactively →