Response to ethanol

Across TCGA cell cohorts, RNA activity of the Response to ethanol pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDAP1, TRMT5, and FRMD6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ethanol activity versus GDAP1 in STOMACH (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GDAP1 →	-1.645	-0.194	.005	.001	3	4
LUNG_NSCLC_LUSC	TRMT5 →	-0.736	-0.216	.008	.001	3	4
BLOOD_Myeloma	FRMD6 →	-3.752	-0.376	.001	.008	3	4
BREAST	MAP1A →	-0.818	-0.166	.009	.003	2	5
BREAST	SNURF →	-3.080	-0.247	<.001	<.001	3	4
BLOOD_Leukemia	MRFAP1 →	-0.324	-0.097	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045471 vs GDAP1 — STOMACH

Explore this scatter interactively →