Myoblast differentiation

Across TCGA patient cohorts, RNA activity of the Myoblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FTLP15, ZDHHC15, and FCF1P3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myoblast differentiation activity versus FTLP15 in CCRCC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FTLP15 →	-1.265	-0.562	.008	.004	3	3
BRCA	ZDHHC15 →	-0.562	-0.224	.002	.001	3	2
BRCA	FCF1P3 →	-0.229	-0.148	.008	.006	3	2
BRCA	RNY3P16 →	+0.847	+0.173	.006	.003	3	2
BRCA	H3C5P →	-0.445	-0.159	<.001	.001	3	2
CCRCC	TNNC2 →	+0.262	+0.516	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045445 vs FTLP15 — CCRCC

Explore this scatter interactively →