Fat cell differentiation

Across TCGA patient cohorts, RNA activity of the Fat cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPCAT3, LOXL1-AS1, and PPM1F, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fat cell differentiation activity versus LPCAT3 in OV (Pearson r = 0.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LPCAT3 →	+0.839	+1.111	.005	.003	3	2
OV	LOXL1-AS1 →	+0.802	+1.056	.002	<.001	3	2
BRCA	PPM1F →	+0.583	+0.290	.005	.004	3	2
COAD	PPFIBP1 →	+0.726	+0.674	<.001	.001	3	2
COAD	ENO2 →	+0.916	+0.749	.002	.001	3	2
COAD	PKD2 →	+1.072	+0.699	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045444 vs LPCAT3 — OV

Explore this scatter interactively →