Cellular respiration

Across TCGA patient cohorts, RNA activity of the Cellular respiration pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SH3BGRL3, PFKFB2_S493, and UBASH3B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular respiration activity versus SH3BGRL3 in HNSC (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SH3BGRL3 →	-0.229	-0.043	.007	.005	3	5
PDAC	PFKFB2_S493 →	+0.417	+0.013	.004	.004	3	5
LSCC	UBASH3B →	-0.254	-0.024	.005	<.001	3	5
LSCC	PTBP2 →	+1.040	+0.029	<.001	.004	3	5
LSCC	RTN4IP1 →	+0.306	+0.028	<.001	.001	3	5
HNSC	RCOR3 →	+0.263	+0.052	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045333 vs SH3BGRL3 — HNSC

Explore this scatter interactively →