Cellular respiration

Across TCGA pan-cancer cohorts, RNA activity of the Cellular respiration pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 241 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Cellular respiration pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and LIHC, show the opposite pattern, with higher activity associated with better survival.

KIRC, UVM, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.503	0.711	<.001	165	view →
UVM	DFS	Tertile	All	0.281	0.711	<.001	106	view →
THCA	OS	Tertile	II,III,IV	0.863	0.970	.005	39	view →
CHOL	DFS	Tertile	II,III,IV	0.219	0.661	.003	36	view →
THYM	OS	Tertile	All	0.774	1.000	.001	30	view →
LUAD	DFS	Median	IV	0.484	0.936	.001	30	view →
KICH	DFS	Quartile	II,III,IV	0.094	1.000	<.001	28	view →
READ	DFS	Quartile	II,III,IV	0.933	0.644	.001	22	view →
COAD	OS	Median	IV	0.271	0.549	.008	21	view →
UCEC	DFS	Tertile	All	0.864	0.914	.009	18	view →
LIHC	OS	Median	II,III,IV	0.630	0.292	.001	15	view →
TGCT	DFS	Tertile	All	0.534	0.805	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0045333–KIRC (DFS)

Open the KIRC breakdown →