Cellular respiration

Across TCGA patient cohorts, RNA activity of the Cellular respiration pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DRP2, DEPDC7, and HOXC13, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular respiration activity versus DRP2 in BRCA (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DRP2 →	-0.455	-0.248	.001	.003	3	2
BRCA	DEPDC7 →	-0.705	-0.203	.002	.009	3	2
BRCA	HOXC13 →	-0.931	-0.151	.007	.004	3	2
BRCA	ACSS2 →	+0.787	+0.223	<.001	<.001	3	2
BRCA	SNRPA1 →	-0.463	-0.188	.002	<.001	3	2
BRCA	PIF1 →	-0.830	-0.200	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045333 vs DRP2 — BRCA

Explore this scatter interactively →