Cellular respiration

Across TCGA cell cohorts, RNA activity of the Cellular respiration pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MICALL1, FBRSL1, and NRARP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MICALL1 grouped by Cellular respiration-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MICALL1 →	-1.187	-0.301	.001	<.001	3	5
BREAST	FBRSL1 →	+1.092	+0.261	<.001	.003	3	5
BREAST	NRARP →	+0.933	+0.246	.004	<.001	3	5
BREAST	PRODH →	+3.282	+0.354	<.001	<.001	3	4
SOFT_TISSUE	GLT8D2 →	-2.721	-0.274	<.001	.001	3	4
SOFT_TISSUE	EFHD2 →	-1.738	-0.273	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MICALL1 by Cellular respiration activity — BREAST

Explore this box plot interactively →