"mRNA cis splicing, via spliceosome"

Across TCGA patient cohorts, RNA activity of the "mRNA cis splicing, via spliceosome" pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RMI1, BRCA2, and DSCC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "mRNA cis splicing, via spliceosome" activity versus RMI1 in GBM (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RMI1 →	+0.792	+0.373	<.001	<.001	3	6
GBM	BRCA2 →	+0.950	+0.366	<.001	<.001	3	6
LSCC	DSCC1 →	+0.753	+0.250	<.001	.009	2	6
LSCC	PRIM2 →	+0.599	+0.286	<.001	.001	3	5
LSCC	MMS22L →	+0.666	+0.232	<.001	.009	3	5
BRCA	CDC25C →	+0.778	+0.224	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045292 vs RMI1 — GBM

Explore this scatter interactively →