"mRNA cis splicing, via spliceosome"

Across TCGA cell cohorts, RNA activity of the "mRNA cis splicing, via spliceosome" pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMK2D, KLHDC3, and ACVR2B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "mRNA cis splicing, via spliceosome" activity versus CAMK2D in PANCREAS (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CAMK2D →	-1.212	-0.166	.002	<.001	3	6
LUNG_NSCLC_LUSC	KLHDC3 →	+0.962	+0.342	.007	.009	2	6
LUNG_SCLC	ACVR2B →	+0.978	+0.185	<.001	<.001	3	5
LUNG_SCLC	PMM2 →	-0.730	-0.176	<.001	.008	3	5
CNS	LGALS3 →	-2.393	-0.223	.002	<.001	3	5
CNS	CLNS1A →	+0.755	+0.215	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045292 vs CAMK2D — PANCREAS

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