Cell-cell junction maintenance

Across TCGA patient cohorts, RNA activity of the Cell-cell junction maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TIMP2, LAMB1, and GPX7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell junction maintenance activity versus TIMP2 in BRCA (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TIMP2 →	+0.624	+0.033	<.001	<.001	3	6
OV	LAMB1 →	+0.465	+0.053	.002	.003	3	6
COAD	GPX7 →	+0.470	+0.034	.002	.003	3	6
OV	PPFIBP1 →	+0.291	+0.051	.006	.001	3	6
HNSC	RAI14 →	+0.338	+0.071	<.001	<.001	3	6
OV	EFEMP1 →	+0.887	+0.065	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045217 vs TIMP2 — BRCA

Explore this scatter interactively →