Cell-cell junction maintenance

Across TCGA cell cohorts, RNA activity of the Cell-cell junction maintenance pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK38L, MAPKAPK3, and SFPQ, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STK38L grouped by Cell-cell junction maintenance-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	STK38L →	+0.162	+1.611	.001	<.001	3	3
BLOOD_Lymphoma	MAPKAPK3 →	-0.329	-1.418	.007	.005	3	3
LARGE_INTESTINE	SFPQ →	+0.392	+0.334	.005	<.001	3	3
SKIN	TOPBP1 →	-0.278	-1.165	<.001	.001	3	3
STOMACH	CFHR3 →	+0.385	+0.397	.002	.001	3	3
LUNG_NSCLC_LUAD	CDX1 →	+0.114	+0.625	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STK38L by Cell-cell junction maintenance activity — SKIN

Explore this box plot interactively →