Cell-cell junction organization

Across TCGA patient cohorts, RNA activity of the Cell-cell junction organization pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NID2, CYGB, and RSU1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell junction organization activity versus NID2 in CCRCC (Pearson r = 0.55).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NID2 →	+0.526	+0.044	<.001	<.001	3	9
OV	CYGB →	+0.604	+0.041	<.001	<.001	3	8
UCEC	RSU1 →	+0.481	+0.046	<.001	.002	3	8
CCRCC	SRP68 →	-0.269	-0.034	<.001	.003	3	8
BRCA	TLN1 →	+0.346	+0.033	<.001	<.001	3	8
UCEC	BGN →	+1.028	+0.057	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045216 vs NID2 — CCRCC

Explore this scatter interactively →