Cell-cell junction organization

Across TCGA cell cohorts, RNA activity of the Cell-cell junction organization pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAAF3, SPACA6, and MRPL53, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAAF3 grouped by Cell-cell junction organization-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNAAF3 →	-1.368	-0.223	.003	<.001	2	4
LARGE_INTESTINE	SPACA6 →	-1.490	-0.199	.002	.003	3	2
LARGE_INTESTINE	MRPL53 →	-0.543	-0.142	.007	.002	3	2
BLOOD_Myeloma	CDC42SE1 →	+0.868	+1.017	.001	.009	3	2
BLOOD_Myeloma	STIMATE →	+0.676	+1.054	.007	.006	3	2
BONE	EIF3A →	+0.526	+0.234	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAAF3 by Cell-cell junction organization activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →