Cell-cell junction organization

Across TCGA cell cohorts, RNA activity of the Cell-cell junction organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABI2, ADGRF1, and NPTN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell junction organization activity versus ABI2 in BLOOD_Leukemia (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ABI2 →	-1.566	-0.265	<.001	<.001	3	7
BREAST	ADGRF1 →	+2.969	+0.203	.002	.005	3	7
BLOOD_Lymphoma	NPTN →	+0.740	+0.160	.002	.009	3	7
URINARY_TRACT	CD9 →	+1.936	+0.207	.006	.008	3	7
BREAST	TBC1D2 →	+1.198	+0.162	.001	.004	2	7
LUNG_NSCLC_LUAD	EPS8L1 →	+1.935	+0.189	.002	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045216 vs ABI2 — BLOOD_Leukemia

Explore this scatter interactively →